Antonio Beltrami

Dr. Beltrami


Researcher and Associate Professor

Dipartimento di scienze mediche e biologiche (DSMB)

e-mail: antonio.beltrami at


APB research interest is focused on the use of adult stem cells for cardiovascular diseases. During his PhD program, he participated in demonstrating the presence of a post-natal cardiac turnover. During his specialization in hematology, he demonstrated that adult human tissues (heart, bone marrow and liver) host a population of widely multipotent cells. In 2009, APB demonstrated that similar cells may be cultured from G-CSF mobilized peripheral blood.More recently APB demonstrated that cardiac resident stem cells isolated from the hearts of patients affected by end-stage heart failure are affected by cell senescence processes that alter their differentiation and migratory abilities. Our aim is to gain insights into the mechanisms involved in stem cell senescence in order to improve our knowledge on the pathophysiology of heart failure. Moreover, we want to rejuvenate stem cells isolated from pathologic hearts to restore their in vivo reparative ability and empower cell therapy.


Recent Publications (since 2012):

1. Bergamin N, Dardis A, Beltrami A, Cesselli D, Rigo S, Zampieri S, Domenis R, Bembi B, Beltrami CA. A human neuronal model of niemann pick c disease developed from stem cells isolated from patient's skin. Orphanet J Rare Dis. 2013;8:34
2. Cesselli D, D'Aurizio F, Marcon P, Bergamin N, Beltrami CA, Beltrami AP. Cardiac stem cell senescence. Methods Mol Biol. 2013;976:81-97
3. Garrovo C, Bergamin N, Bates D, Cesselli D, Beltrami AP, Lorenzon A, Ferrari R, Alberto Beltrami C, Lorusso V, Biffi S. In vivo tracking of murine adipose tissue-derived multipotent adult stem cells and ex vivo cross-validation. Int J Mol Imaging. 2013;2013:426961
4. Spinetti G, Cordella D, Fortunato O, Sangalli E, Losa S, Gotti A, Carnelli F, Rosa F, Riboldi S, Sessa F, Avolio E, Beltrami AP, Emanueli C, Madeddu P. Global remodeling of the vascular stem cell niche in bone marrow of diabetic patients: Implication of the microrna-155/foxo3a signaling pathway. Circ Res. 2013;112:510-522
5. Zeppieri M, Salvetat ML, Beltrami AP, Cesselli D, Bergamin N, Russo R, Cavaliere F, Varano GP, Alcalde I, Merayo J, Brusini P, Beltrami CA, Parodi PC. Human adipose-derived stem cells for the treatment of chemically burned rat cornea: Preliminary results. Curr Eye Res. 2013
6. Rajesh Katare, Atsuhiko Oikawa, Daniela Cesselli, Antonio P. Beltrami, Elisa Avolio, Deepti Muthukrishnan, Pujika Emani Munasinghe, Gianni Angelini, Costanza Emanueli, and Paolo Madeddu. Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes. Cardiovasc Res first published online September 20, 2012 doi:10.1093/cvr/cvs291
7. Ferro F, Spelat R, D'Aurizio F, Puppato E, Pandolfi M, Antonio Paolo Beltrami, Daniela Cesselli, Giuseppe Falini, Carlo Alberto Beltrami, Francesco Curcio. (2012) Dental Pulp Stem Cells Differentiation Reveals New Insights in Oct4A Dynamics. PLoS ONE 7(7): e41774. doi:10.1371/journal.pone.0041774
8. Federico Ferro, Renza Spelat, Federica D'Aurizio, Giuseppe Falini, Ilaria De Pol, Maura Pandolfi, Antonio Paolo Beltrami, Daniela Cesselli, Carlo Alberto Beltrami, and Francesco Curcio. Acellular Bone Colonization and Aggregate Culture Conditions Diversely Influence Murine Periosteum Mesenchymal Stem Cell Differentiation Potential in Long-Term In Vitro Osteoinductive Conditions. Tissue Engineering Part A. July 2012, 18(13-14): 1509-1519. doi:10.1089/ten.tea.2011.0411.
9. Baccarani, Umberto; Beltrami, Antonio Paolo Human Unrestricted Somatic Stem Cells: How Far from Clinics? ASAIO Journal. May/June 2012 - Volume 58 - Issue 3 - p 181–182; doi: 10.1097/MAT.0b013e3182545d1d
10. Beltrami AP, Cesselli D, Beltrami CA (2012) Cardiac Resident Stem Cells: Work (Still) in Progress. J Stem Cell Res Ther S9:001. doi:10.4172/2157-7633.S9-001
11. AMADESI, S., RENI, C., KATARE, R., MELONI, M., OIKAWA, A., BELTRAMI, A. P., ET AL. (2012). Role for Substance-P Based Nociceptive Signaling in Progenitor Cell Activation and Angiogenesis during Ischemia in Mice and in Human Subjects. Circulation. DOI: CIRCULATIONAHA.111.089763 [pii] 10.1161/CIRCULATIONAHA.111.089763
12. Beltrami AP, Cesselli D, Beltrami CA. Stem cell senescence and regenerative paradigms. Clin Pharmacol Ther. 2012;91:21-29.

Monalisa Group

Department of Medical and Biological Sciences - University of Udine - Piazzale Kolbe, 4 - 33100 Udine - Italy

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